Last edited by Mausida
Wednesday, August 5, 2020 | History

5 edition of Adenoviral vectors for gene therapy found in the catalog.

Adenoviral vectors for gene therapy

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  • 12 Currently reading

Published by Academic Press in Amsterdam, Boston .
Written in English

    Subjects:
  • Gene therapy,
  • Adenoviruses

  • Edition Notes

    Includes bibliographical references

    Statementedited by David T. Curiel, Joanne T. Douglas
    ContributionsCuriel, David, Douglas, Joanne T
    Classifications
    LC ClassificationsRB155.8 .A34 2002
    The Physical Object
    Paginationxxviii, 677 p. [12] p. of plates :
    Number of Pages677
    ID Numbers
    Open LibraryOL17046449M
    ISBN 100121995046
    LC Control Number2001098272

    Most chapters in the book end with a conclusion and a few thoughts on the future prospects for research and therapy. Given the recent tragic death of a patient receiving an adenovirus vector and the subsequent scrutiny of gene therapy clinical trials, it is necessary to ask what future adenovirus vectors will have in gene : Matthew D. Weitzman. Keywords:adenovirus, adenoviral vector, cancer gene therapy, foreign cdna, viral vector Abstract: Cancer gene therapy is considered a very viable approach for the treatment of cancer. The basic idea is to introduce the therapeutic gene, often in the form of a foreign cDNA, into .

    The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. To overcome the low in vivo transduction efficiency of the retrovirus, recombinant adenoviral vectors have been used to transfer the HSV-tk gene into tumor cells. This approach, evaluated in mice, was very efficient in mediating the regression of a variety of tumors (17 – 20).

      Adenoviral packaging vectors are attractive options for human gene therapy trials since they show low pathogenicity, high viral yields, carry large genes, and show transgene specific B and T . Conclusion. Since the original idea of vector-based gene therapy, a great deal of progress in adenoviral vector development has been made. Judging from the published work using the adenoviral vectors, it is apparent that the existing adenoviral vectors have provided excellent tools to learn the basic science of cancer gene therapy; and will most likely find some applications in the clinical.


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Adenoviral vectors for gene therapy Download PDF EPUB FB2

This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials.

Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal.

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research.

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for : $ Adenovirus vectors are the most commonly employed vector for cancer gene therapy.

They are also used for gene therapy and as vaccines to express foreign antigens. Adenovirus vectors can be replication-defective; certain essential viral genes are deleted and replaced by a cassette that expresses a foreign therapeutic by: Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy.

These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for cturer: Academic Press. Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents.

The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be 5/5(1).

Get this from a library. Adenoviral vectors for gene therapy. [David Curiel;] -- "[This book] provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy.

These exciting new. Figure 3. Gene therapy using an Adenovirus vector. In September,the gene therapy research community was alerted to the report of the death of a man enrolled in a gene transfer trial at the University of Pennsylvania. The Recombinant DNA Advisory Committee has published a review which involves a discussion of the preclinical safety data.

This property of adenoviral vectors is extremely important in gene therapy and puts adenoviral vectors on top of viral vectors for gene delivery.

Furthermore, adenovirus vectors do not integrate into host genomes but stay as episomal DNA in the nucleus of host : Shakti Singh, Rakesh Kumar, Babita Agrawal.

This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials.

ISBN: OCLC Number: Description: xxviii, pages: illustrations ; 24 cm: Contents: Adenovirus structure / Phoebe L. Stewart --Biology of adenovirus cell entry / Glen R.

Nemerow --Adenovirus replication / Jared D. Evans --Adenoviral vector construction I: mammalian systems / Philip Ng --Adenoviral vector construction II: bacterial systems / M.

Lusky. Gendicine, an adenoviral pbased gene therapy was approved by the Chinese food and drug regulators in for treatment of head and neck cancer. Advexin, a similar gene therapy approach from Introgen, was turned down by the US Food and Drug Administration (FDA) in   Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents.

The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be Book Edition: 1.

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy.

These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for : Elsevier Science. Adenoviral Vector-Based Vaccines and Gene Therapies: Current Status and Future Prospects 11 are ongoing with adenoviral vectors (T able 1).

The previous generation of adenoviral vec. Vectors based on human adenovirus serotypes 2 (Ad2) and 5 (Ad5) of species C possess a number of features that have favored their widespread employment for gene delivery both in␣vitro and in␣vivo.

However, the use of recombinant Ad2- and Ad5-based vectors for gene therapy also suffers from a number of disadvantages. These vectors possess the tropism of the parental viruses, which Cited by:   Adenoviral vectors. Targeting adenoviral vectors.

Clinical applications of adenoviral gene therapy. Adenoviral vectors for immunotherapy. Adenoviral vectors for suicide gene therapy. Adenoviral vectors for gene replacement therapy. Oncolytic adenoviral therapy. Adverse outcomes of adenoviral gene therapy.

Summary. References. Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool.

With the first licensing of clinical adenoviral gene therapy for cancer treatment the use of adenoviruses is likely to expand in the future. This chapter focuses on the history of adenovirus development, interactions with the host both for gene delivery and immunogenicity as well as potential therapeutic applications.

How to Cite. Havenga, M. J. E., Vogels, R., Bout, A. and Mehtali, M. () Pseudotyping of Adenoviral Vectors, in Vector Targeting for Therapeutic Gene Delivery (eds.Gene Therapy of Glioblastoma Multiforme - Clinical Experience on the Use of Adenoviral Vectors.

By Thomas Wirth and Seppo Ylä-Herttuala. Submitted: November 11th Reviewed: April 11th Published: August 23rd DOI: /Author: Thomas Wirth, Seppo Ylä-Herttuala.Adenoviral vectors will transduce a wide range of target cells resulting in high-level gene expression.

They are non-integrating vectors so expression in dividing cells is progressively lost. First generation vectors may be suitable for applications where transient, high level activity is sufficient, and where immune responses to the vector or.